The role universities can play in supporting the state sector

Over recent decades most of the developed world has invested significantly in lifting the proportion of the population that has a tertiary education, with a view to increasing what is commonly referred to as human capital. The OECD defines human capital as ‘the knowledge, skills, competencies and attributes embodied in individuals that facilitate the creation of personal, social and economic well-being’ (OECD, 2001) New Zealand spends around 1% of its the proportion of the population with a GDP on tertiary education (OECD, tertiary qualification over the past couple 2014) and has seen a significant rise in the proportion of the population with a tertiary qualification over the past couple of decades. In 1991, 8.2% of the working-age population had a degree at bachelor’s level or higher (Statistics New Zealand, 1991). By 2013 this had risen to 26.1%. In 1991, having a degree was a way of differentiating oneself to an employer; now it is an expectation for many jobs, including an increasing number in the state sector. This article considers the educational profile of the state sector’s employees at the time of the 2013 census, and examines the ways universities are contributing to this profile and to lifting the human capital available to the state sector. • Chris Whelan is the Executive Director of Universities New Zealand – Te Päkai Tara

Active charge air cooling

Boosted IC engine development, both diesel and gasoline, is driving the need for better charge air temperature control. Charge air temperature directly and indirectly influences engine performance, fuel economy & emissions. To date charge air temperature control has, in the main, been passive; aiming only to reduce temperatures towards, but still above, ambient temperature. Driven by increasing specific output, the opportunities for sub-ambient charge cooling need to be investigated. For some real world driving conditions it is also desirable to raise the charge temperature. Air Cycle Technology ltd (ACT), working with the University of Huddersfield (UoH) are developing a controllable charge air cooling system, which will deliver charge air at sub-ambient temperature over a wide engine operating range. The system uses a turbo-expander to deliver air-cycle cooling in a simple and practical way. The system can be enhanced by combination with a charge air heating process. Accurate charge temperature control over as wide an engine operating range as possible is also addressed. The system is fully compatible with the operational, packaging and cost needs of vehicle OEMs. The paper presents the principle, process and application of a controllable charge air cooling/heating system. It covers the design and operation of the turbo-expander which delivers sub-ambient charge temperatures, the option of charge air heating and possible control methods. Examples of specific engine applications are presented to clearly indicate the opportunities for improvements in engine performance and fuel economy

Continuous-flow laboratory simulation of stream water quality changes downstream of an untreated wastewater discharge.

In regions of the world with poor provision of wastewater treatment, raw sewage is often discharged directly into surface waters. This paper describes an experimental evaluation of the fate of two organic chemicals under these conditions using an artificial channel cascade fed with a mix of settled sewage and river water at its upstream end and operated under continuous steady-state conditions. The experiments underpin an environmental risk assessment methodology based on the idea of an “impact zone” (IZ) – the zone downstream of wastewater emission in which water quality is severely impaired by high concentrations of unionised ammonia, nitrite and biochemical oxygen demand (BOD). Radiolabelled dodecane-6-benzene sulphonate (DOBS) and aniline hydrochloride were used as the model chemical and reference compound respectively. Rapid changes in 14C counts were observed with flow-time for both these materials. These changes were most likely to be due to complete mineralisation. A dissipation half-life of approximately 7.1 h was observed for the 14C label with DOBS. The end of the IZ was defined as the point at which the concentration of both unionised ammonia and nitrite fell below their respective predicted no-effect concentrations for salmonids. At these points in the cascade, approximately 83 and 90% of the initial concentration of 14C had been removed from the water column, respectively. A simple model of mineral nitrogen transformations based on Michaelis–Menten kinetics was fitted to observed concentrations of NH4, NO2 and NO3. The cascade is intended to provide a confirmatory methodology for assessing the ecological risks of chemicals under direct discharge co

An in silico analysis of the mitochondrial protein import apparatus of plants

<p>Abstract</p> <p>Background</p> <p>An <it>in silico </it>analysis of the mitochondrial protein import apparatus from a variety of species; including <it>Chlamydomonas reinhardtii</it>, <it>Chlorella variabilis, Ectocarpus siliculosus</it>, <it>Cyanidioschyzon merolae</it>, <it>Physcomitrella patens</it>, <it>Selaginella moellendorffii, Picea glauca</it>, <it>Oryza sativa </it>and <it>Arabidopsis thaliana </it>was undertaken to determine if components differed within and between plant and non-plant species.</p> <p>Results</p> <p>The channel forming subunits of the outer membrane components Tom40 and Sam50 are conserved between plant groups and other eukaryotes. In contrast, the receptor component(s) in green plants, particularly Tom20, (<it>C. reinhardtii, C. variabilis, P. patens, S. moellendorffii, P. glauca, O. sativa and A. thaliana</it>) are specific to this lineage. Red algae contain a Tom22 receptor that is orthologous to yeast Tom22. Furthermore, plant mitochondrial receptors display differences between various plant lineages. These are evidenced by distinctive motifs in all plant Metaxins, which are absent in red algae, and the presence of the outer membrane receptor OM64 in Angiosperms (rice and Arabidopsis), but not in lycophytes (<it>S. moellendorffii</it>) and gymnosperms (<it>P. glauca</it>). Furthermore, although the intermembrane space receptor Mia40 is conserved across a wide phylogenetic range, its function differs between lineages. In all plant lineages, Tim17 contains a C-terminal extension, which may act as a receptor component for the import of nucleic acids into plant mitochondria.</p> <p>Conclusions</p> <p>It is proposed that the observed functional divergences are due to the selective pressure to sort proteins between mitochondria and chloroplasts, resulting in differences in protein receptor components between plant groups and other organisms. Additionally, diversity of receptor components is observed within the plant kingdom. Even when receptor components are orthologous across plant and non-plant species, it appears that the functions of these have expanded or diverged in a lineage specific manner.</p

The dual targeting ability of type II NAD(P)H dehydrogenases arose early in land plant evolution

Background: Type II NAD(PH) dehydrogenases are located on the inner mitochondrial membrane of plants, fungi, protists and some primitive animals. However, recent observations have been made which identify several Arabidopsis type II dehydrogenases as dual targeted proteins. Targeting either mitochondria and peroxisomes or mitochondria and chloroplasts. Results: Members of the ND protein family were identified in various plant species. Phylogenetic analyses and subcellular targeting predictions were carried out for all proteins. All ND proteins from three model plant species Arabidopsis, rice and Physcomitrella were cloned as N- and C-terminal GFP fusions and subcellular localisations were determined. Dual targeting of plant type II dehydrogenases was observed to have evolved early in plant evolution and to be widespread throughout different plant species. In all three species tested dual targeting to both mitochondria and peroxisomes was found for at least one NDA and NDB type protein. In addition two NDB type proteins from Physcomitrella were also found to target chloroplasts. The dual targeting of NDC type proteins was found to have evolved later in plant evolution. Conclusions: The functions of type II dehydrogenases within plant cells will have to be re-evaluated in light of this newly identified subcellular targeting information

The impact of introducing hydrodistension as a treatment for frozen shoulder in a primary care musculoskeletal service: a retrospective audit

Introduction Hydrodistension, where a relatively high volume of local anaesthetic, corticosteroid, and sterile saline are injected into the shoulder joint, is a treatment of interest for frozen shoulder. In the UK National Health Service this is typically provided in the hospital setting. In 2017 we introduced hydrodistension into our physiotherapy led musculoskeletal service. This report describes the findings from our audit of onward referral for orthopaedic assessment following the introduction of hydrodistension to our frozen shoulder treatment pathway. Methods A retrospective audit of data from 102 patients who followed our hydrodistension treatment pathway for frozen shoulder since 2017 was conducted. All 102 patients received at least one hydrodistension procedure performed by a physiotherapist. This involved injecting the glenohumeral joint with a combination of local anaesthetic, corticosteroid, and saline under ultrasound guidance with a total volume of 25–35 mls. This data was compared to the outcomes of 102 patients who presented with frozen shoulder prior to 2017 who did not receive hydrodistension. Results Of 102 patients who received hydrodistension within the musculoskeletal service, six patients required onward referral to orthopaedics. Of the 102 patients who did not receive hydrodistension prior to 2017, 58 required onward referral to orthopaedics. Conclusion We report a reduction in onward referral to orthopaedics following the introduction of hydrodistension to our physiotherapist-led treatment pathway for patients with frozen shoulder. This preliminary data identifies the need to further evaluate the clinical and cost-effectiveness of hydrodistension performed by physiotherapists for patients with frozen shoulder

Quantifying tropical peatland dissolved organic carbon (DOC) using UV-visible spectroscopy

UV–visible spectroscopy has been shown to be a useful technique for determining dissolved organic carbon (DOC) concentrations. However, at present we are unaware of any studies in the literature that have investigated the suitability of this approach for tropical DOC water samples from any tropical peatlands, although some work has been performed in other tropical environments. We used water samples from two oil palm estates in Sarawak, Malaysia to: i) investigate the suitability of both single and two-wavelength proxies for tropical DOC determination; ii) develop a calibration dataset and set of parameters to calculate DOC concentrations indirectly; iii) provide tropical researchers with guidance on the best spectrophotometric approaches to use in future analyses of DOC. Both single and two-wavelength model approaches performed well with no one model significantly outperforming the other. The predictive ability of the models suggests that UV–visible spectroscopy is both a viable and low cost method for rapidly analyzing DOC in water samples immediately post-collection, which can be important when working at remote field sites with access to only basic laboratory facilities

Faecal and urine metabolites, but not gut microbiota, may predict response to low FODMAP diet in irritable bowel syndrome

BackgroundThe low FODMAP diet (LFD) leads to clinical response in 50%-80% of patients with irritable bowel syndrome (IBS). It is unclear why only some patients respond.AimsTo determine if differences in baseline faecal microbiota or faecal and urine metabolite profiles may separate clinical responders to the diet from non-responders allowing predictive algorithms to be proposed.MethodsWe recruited adults fulfilling Rome III criteria for IBS to a blinded randomised controlled trial. Patients were randomised to sham diet with a placebo supplement (control) or LFD supplemented with either placebo (LFD) or 1.8 g/d B-galactooligosaccharide (LFD/B-GOS), for 4 weeks. Clinical response was defined as adequate symptom relief at 4 weeks after the intervention (global symptom question). Differences between responders and non-responders in faecal microbiota (FISH, 16S rRNA sequencing) and faecal (gas-liquid chromatography, gas-chromatography mass-spectrometry) and urine (1 H NMR) metabolites were analysed.ResultsAt 4 weeks, clinical response differed across the 3groups with adequate symptom relief of 30% (7/23) in controls, 50% (11/22) in the LFD group and 67% (16/24) in the LFD/B-GOS group (p = 0.048). In the control and the LFD/B-GOS groups, microbiota and metabolites did not separate responders from non-responders. In the LFD group, higher baseline faecal propionate (sensitivity 91%, specificity 89%) and cyclohexanecarboxylic acid esters (sensitivity 80%, specificity 78%), and urine metabolite profile (Q2 0.296 vs. randomised -0.175) predicted clinical response.ConclusionsBaseline faecal and urine metabolites may predict response to the LFD

On Type Ia Supernovae From The Collisions of Two White Dwarfs

We explore collisions between two white dwarfs as a pathway for making Type Ia Supernovae (SNIa). White dwarf number densities in globular clusters allow 10-100 redshift <1 collisions per year, and observations by (Chomiuk et al. 2008) of globular clusters in the nearby S0 galaxy NGC 7457 have detected what is likely to be a SNIa remnant. We carry out simulations of the collision between two 0.6 solar mass white dwarfs at various impact parameters and mass resolutions. For impact parameters less than half the radius of the white dwarf, we find such collisions produce approximately 0.4 solar masses of Ni56, making such events potential candidates for underluminous SNIa or a new class of transients between Novae and SNIa.Comment: 4 pages, 4 figures, 1 tabl

A molecular map of mesenchymal tumors

BACKGROUND: Bone and soft tissue tumors represent a diverse group of neoplasms thought to derive from cells of the mesenchyme or neural crest. Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy. RESULTS: We have undertaken a broad and comprehensive study of the gene expression profile of 96 tumors with representatives of all mesenchymal tissues, including several problem diagnostic groups. Using machine learning methods adapted to this problem we identify molecular fingerprints for most tumors, which are pathognomonic (decisive) and biologically revealing. CONCLUSION: We demonstrate the utility of gene expression profiles and machine learning for a complex clinical problem, and identify putative origins for certain mesenchymal tumors